解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:In the model legume Medicago truncatula, the near saturation genome-wide Tnt1 insertion mutant population in ecotype R108 is a valuable tool in functional genomics studies. Forward genetic screens have identified many Tnt1 mutants defective in nodule development and symbiotic nitrogen fixation (SNF). However...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2452-5
更新日期:2016-02-27 00:00:00
abstract:BACKGROUND:Yarrowia lipolytica is an oleaginous ascomycete yeast that stores lipids in response to limitation of nitrogen. While the enzymatic pathways responsible for neutral lipid accumulation in Y. lipolytica are well characterized, regulation of these pathways has received little attention. We therefore sought to c...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2471-2
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:Osteoporosis is a common and debilitating bone disease that is characterised by a low bone mineral density (BMD), a highly heritable trait. Genome-wide association studies (GWAS) have proven to be very successful in identifying common genetic variants associated with BMD adjusted for age, gender and weight, ...
journal_title:BMC genomics
pub_type: 杂志文章,meta分析
doi:10.1186/s12864-016-2481-0
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:Theileria parva is an intracellular parasite that causes a lymphoproliferative disease in cattle. It does so by inducing cancer-like phenotypes in the host cells it infects, although the molecular and regulatory mechanisms involved remain poorly understood. RNAseq data, and the resulting updated genome annot...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2444-5
更新日期:2016-02-20 00:00:00
abstract:BACKGROUND:Progress in genetics and breeding in pea still suffers from the limited availability of molecular resources. SNP markers that can be identified through affordable sequencing processes, without the need for prior genome reduction or a reference genome to assemble sequencing data would allow the discovery and ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2447-2
更新日期:2016-02-18 00:00:00
abstract:BACKGROUND:Alternative σ factors are important transcriptional regulators in bacteria. While σ(B) has been shown to control a large regulon and play important roles in stress response and virulence in the pathogen Listeria monocytogenes, the function of σ(H) has not yet been well defined in Listeria, even though σ(H) c...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2432-9
更新日期:2016-02-16 00:00:00
abstract:BACKGROUND:A high caloric diet, in conjunction with low levels of physical activity, promotes obesity. Many studies are available regarding the relation between dietary saturated fats and the etiology of obesity, but most focus on liver, muscle and white adipose tissue. Furthermore, the majority of transcriptomic studi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2424-9
更新日期:2016-02-09 00:00:00
abstract:BACKGROUND:Sugarcane is an economically important crop contributing to about 80% of the world sugar production. Increasing efforts in molecular biological studies have been performed for improving the sugar yield and other relevant important agronomic traits. However, due to sugarcane's complicated genomes, it is still...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2419-6
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Circannual rhythms in vertebrates can influence a wide variety of physiological processes. Some notable examples include annual reproductive cycles and for poikilotherms, seasonal changes modulating growth. Increasing water temperature elevates growth rates in fishes, but increases in photoperiod regime can ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2363-5
更新日期:2016-01-15 00:00:00
abstract:BACKGROUND:With advances in next generation sequencing technology and analysis methods, single nucleotide variants (SNVs) and indels can be detected with high sensitivity and specificity in exome sequencing data. Recent studies have demonstrated the ability to detect disease-causing copy number variants (CNVs) in exome...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2374-2
更新日期:2016-01-14 00:00:00
abstract:BACKGROUND:The genetic mechanisms underlying hemangioblastoma development are still largely unknown. We used high-resolution single nucleotide polymorphism microarrays and droplet digital PCR analysis to detect copy number variations (CNVs) in total of 45 hemangioblastoma tumors. RESULTS:We identified 94 CNVs with a m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2370-6
更新日期:2016-01-14 00:00:00
abstract:BACKGROUND:Small RNAs (sRNAs) have emerged as important regulatory molecules and have been studied in several bacteria. However, to date, there have been no whole-transcriptome studies on sRNAs in any of the Soft Rot Enterobacteriaceae (SRE) group of pathogens. Although the main ecological niches for these pathogens ar...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2376-0
更新日期:2016-01-12 00:00:00
abstract:BACKGROUND:Auxin plays a critical role in inducing adventitious rooting in many plants. Indole-3-butyric acid (IBA) is the most widely employed auxin for adventitious rooting. However, the molecular mechanisms by which auxin regulate the process of adventitious rooting are less well known. RESULTS:The RNA-Seq data ana...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2372-4
更新日期:2016-01-12 00:00:00
abstract:BACKGROUND:Several in vitro studies document the function of the transcriptional regulator TrmBL1 of Pyrococcus furiosus. These data indicate that the protein can act as repressor or activator and is mainly involved in transcriptional control of sugar uptake and in the switch between glycolysis and gluconeogenesis. The...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2360-0
更新日期:2016-01-08 00:00:00
abstract:BACKGROUND:The microsporidian Encephalitozoon cuniculi is an obligate intracellular eukaryotic pathogen with a small nuclear genome (2.9 Mbp) consisting of 11 chromosomes. Although each chromosome end is known to contain a single rDNA unit, the incomplete assembly of subtelomeric regions following sequencing of the gen...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1920-7
更新日期:2016-01-07 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs that regulate genes at the post-transcriptional level in spatiotemporal manner. Several miRNAs are identified as prognostic and diagnostic markers in many human cancers. Estimation of the temporal activities of the miRNAs is an important step in the way to underst...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2260-3
更新日期:2015-12-18 00:00:00
abstract:BACKGROUND:Genotyping-by-sequencing (GBS) is becoming an attractive alternative to array-based methods for genotyping individuals for a large number of single nucleotide polymorphisms (SNPs). Costs can be lowered by reducing the mean sequencing depth, but this results in genotype calls of lower quality. A common analys...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2252-3
更新日期:2015-12-09 00:00:00
abstract:BACKGROUND:The Egyptian Rousette bat (Rousettus aegyptiacus), a common fruit bat species found throughout Africa and the Middle East, was recently identified as a natural reservoir host of Marburg virus. With Ebola virus, Marburg virus is a member of the family Filoviridae that causes severe hemorrhagic fever disease i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2124-x
更新日期:2015-12-07 00:00:00
abstract:BACKGROUND:Nicotiana benthamiana is a widely used model plant species for research on plant-pathogen interactions as well as other areas of plant science. It can be easily transformed or agroinfiltrated, therefore it is commonly used in studies requiring protein localization, interaction, or plant-based systems for pro...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2209-6
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Genomic selection based on genotyping-by-sequencing (GBS) data could accelerate alfalfa yield gains, if it displayed moderate ability to predict parent breeding values. Its interest would be enhanced by predicting ability also for germplasm/reference populations other than those for which it was defined. Pre...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2212-y
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Whole-exome sequencing (WES) is rapidly evolving into a tool of choice for rapid, and inexpensive identification of molecular genetic lesions within targeted regions of the human genome. While biases in WES coverage of nucleotides in targeted regions are recognized, it is not well understood how repetition o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2107-y
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:Circular chromosome conformation capture (4C) has provided important insights into three dimensional (3D) genome organization and its critical impact on the regulation of gene expression. We developed a new quantitative framework based on polymer physics for the analysis of paired-end sequencing 4C (PE-4Cseq...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2137-5
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:HPA axis plays a major role in physiological homeostasis. It is also involved in stress and adaptive response to the environment. In farm animals in general and specifically in pigs, breeding strategies have highly favored production traits such as lean growth rate, feed efficiency and prolificacy at the cos...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2118-8
更新日期:2015-11-17 00:00:00
abstract:BACKGROUND:The steroid hormone environment in healthy horses seems to have a significant impact on the efficiency of their uterine immune response. The objective of this study was to characterize the changes in gene expression in the equine endometrium in response to the introduction of bacterial pathogens and the infl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2139-3
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Dinoflagellates are unicellular marine and freshwater eukaryotes. They possess large nuclear genomes (1.5-245 gigabases) and produce structurally unique and biologically active polyketide secondary metabolites. Although polyketide biosynthesis is well studied in terrestrial and freshwater organisms, only rec...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2195-8
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Filarial nematodes cause debilitating human diseases. While treatable, recent evidence suggests drug resistance is developing, necessitating the development of novel targets and new treatment options. Although transcriptomic and proteomic studies around the nematode life cycle have greatly enhanced our knowl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2083-2
更新日期:2015-11-11 00:00:00
abstract:BACKGROUND:Hypoxia Inducible Factor (HIF) regulates a cascade of transcriptional events in response to decreased oxygenation, acting from the cellular to the physiological level. This response is evolutionarily conserved, allowing the use of zebrafish (Danio rerio) as a model for studying the hypoxic response. Activati...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2169-x
更新日期:2015-11-11 00:00:00
abstract:BACKGROUND:The increased multi-omics information on carefully phenotyped patients in studies of complex diseases requires novel methods for data integration. Unlike continuous intensity measurements from most omics data sets, phenome data contain clinical variables that are binary, ordinal and categorical. RESULTS:In ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2170-4
更新日期:2015-11-11 00:00:00
abstract:BACKGROUND:The σ(54) subunit controls a unique class of promoters in bacteria. Such promoters, without exception, require enhancer binding proteins (EBPs) for transcription initiation. Desulfovibrio vulgaris Hildenborough, a model bacterium for sulfate reduction studies, has a high number of EBPs, more than most sequen...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2176-y
更新日期:2015-11-10 00:00:00
abstract:BACKGROUND:The MHC and KIR loci are clinically relevant regions of the genome. Typing the sequence of these loci has a wide range of applications including organ transplantation, drug discovery, pharmacogenomics and furthering fundamental research in immune genetics. Rapid advances in biochemical and next-generation se...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1949-7
更新日期:2015-11-05 00:00:00
abstract:BACKGROUND:Most studies on the paper mulberry are mainly focused on the medicated and pharmacology, fiber quality, leaves feed development, little is known about its mechanism of adaptability to abiotic stress. Physiological measurement, transcriptomics and proteomic analysis were employed to understand its response to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2047-6
更新日期:2015-11-05 00:00:00
abstract:BACKGROUND:Next generation sequencing (NGS) technology has been rapidly introduced into basic and translational research in oncology, but the reduced availability of fresh frozen (FF) tumor tissues and the poor quality of DNA extracted from formalin-fixed, paraffin-embedded (FFPE) has significantly impaired this proces...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1982-6
更新日期:2015-11-03 00:00:00
abstract:BACKGROUND:Copy number variation (CNV) is a major component of genomic variation, yet methods to accurately type genomic CNV lag behind methods that type single nucleotide variation. High-throughput sequencing can contribute to these methods by using sequence read depth, which takes the number of reads that map to a gi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2123-y
更新日期:2015-11-02 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provide new inf...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2058-3
更新日期:2015-10-28 00:00:00
abstract:BACKGROUND:Bixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L. An enzymatic pathway for bixin biosynthesis was inferred from homology of putative proteins encoded by differentially expressed seed cDNAs. Some activities we...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2065-4
更新日期:2015-10-28 00:00:00
abstract:BACKGROUND:Moraxella catarrhalis is an important pathogen that often causes otitis media in children, a disease that is not currently vaccine preventable. Asymptomatic colonisation of the human upper respiratory tract is common and lack of clearance by the immune system is likely due to the emergence of seroresistant g...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2104-1
更新日期:2015-10-24 00:00:00
abstract:BACKGROUND:5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate. The EPSPS genes of allohexaploid wheat (Triticum aestivum, AABBDD) have not been well characterized. Herein, the three homoeologous cop...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2084-1
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Sensory hair cells are exquisitely sensitive to mechanical stimuli and as such, are prone to damage and apoptosis during dissections or in vitro manipulations. Thiouracil (TU)-tagging is a noninvasive method to label cell type-specific transcripts in an intact organism, thereby meeting the challenge of how t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2072-5
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Two-component systems (TCS) play critical roles in sensing and responding to environmental cues. Azospirillum is a plant growth-promoting rhizobacterium living in the rhizosphere of many important crops. Despite numerous studies about its plant beneficial properties, little is known about how the bacterium s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1962-x
更新日期:2015-10-22 00:00:00
abstract:BACKGROUND:Bifidobacterial genome analysis has provided insights as to how these gut commensals adapt to and persist in the human GIT, while also revealing genetic diversity among members of a given bifidobacterial (sub)species. Bifidobacteria are notoriously recalcitrant to genetic modification, which prevents explora...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1968-4
更新日期:2015-10-21 00:00:00